For a patient experiencing anaphylactic shock, which drug is the most appropriate treatment?

Prepare for the Lippincott Pharmacology Exam with interactive flashcards and multiple-choice questions, each accompanied by detailed hints and explanations. Master your exam with ease!

In the case of anaphylactic shock, epinephrine is the most appropriate treatment due to its rapid action and the specific physiological effects it has on the body. Anaphylaxis is characterized by severe allergic reactions leading to symptoms such as bronchospasm, vasodilation, and increased vascular permeability, which can rapidly result in airway obstruction, hypotension, and shock.

Epinephrine, being a non-selective adrenergic agonist, stimulates both alpha and beta adrenergic receptors. The activation of alpha-1 receptors leads to vasoconstriction, which helps to counteract the hypotension seen in anaphylaxis. Stimulation of beta-1 receptors increases heart rate and myocardial contractility, thus improving cardiac output. Additionally, the stimulation of beta-2 receptors results in bronchodilation, which alleviates respiratory distress and improves airflow.

This multifaceted approach provided by epinephrine is critical in managing the life-threatening symptoms of anaphylaxis effectively and swiftly. Onset of action is rapid, typically within minutes, making epinephrine the first-line treatment in emergency situations involving severe allergic reactions.

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