What anesthetic drug is best for maintenance in a patient with a history of postoperative nausea and vomiting?

Propofol is the best choice for maintenance anesthesia in a patient with a history of postoperative nausea and vomiting because it has antiemetic properties, which help reduce the likelihood of nausea and vomiting after surgery. This characteristic makes it particularly suitable for patients who are predisposed to these complications.

Additionally, Propofol has a rapid onset and a quick recovery time, allowing for smooth transitions in and out of anesthesia, which can further contribute to a more favorable postoperative experience. Its use can help minimize the potential for delayed recovery associated with other anesthetics that may not possess the same antiemetic benefits.

In contrast, other anesthetics, such as isoflurane and sevoflurane, are associated with a higher incidence of postoperative nausea and vomiting. While nitrous oxide can also be helpful in certain situations, it is not typically used alone for maintenance due to its diffusive nature and potential side effects. Therefore, the characteristics of Propofol make it the most appropriate choice for patients vulnerable to nausea and vomiting after surgical procedures.