What condition might daptomycin treatment necessitate due to one of its adverse effects?

Daptomycin is an antimicrobial agent used to treat certain bacterial infections, particularly those caused by Gram-positive bacteria. While daptomycin is generally well-tolerated, it can lead to muscle-related side effects, with one of the most significant being rhabdomyolysis. This condition occurs when muscle tissue breaks down and releases myoglobin into the bloodstream, potentially leading to severe complications, including kidney damage.

The risk of rhabdomyolysis is particularly relevant because daptomycin treatment is associated with elevations in creatine phosphokinase (CPK) levels, which indicates muscle damage. Therefore, healthcare providers monitor CPK levels closely during daptomycin therapy. If significant elevations are observed or if the patient exhibits symptoms suggestive of muscle injury (such as muscle pain or weakness), it may necessitate further interventions to prevent complications associated with rhabdomyolysis, such as acute kidney injury.

Monitoring for ototoxicity is more commonly associated with other antibiotics, such as aminoglycosides. Red man syndrome is associated with vancomycin, characterized by infusion-related reactions. QTc prolongation is primarily a concern with certain other medications, such as some antipsychotics or antibiotics like azithromycin