What contributes to osteoporosis with long-term use of glucocorticoids?

Long-term use of glucocorticoids is known to contribute to osteoporosis primarily due to their inhibition of calcium absorption in the intestines. Glucocorticoids affect various metabolic processes, one of which is the modulation of calcium metabolism. When calcium absorption is inhibited, less calcium is available for the body, which can lead to decreased bone density and strength over time, thereby increasing the risk of developing osteoporosis.

In addition to inhibiting calcium absorption, glucocorticoids also have other effects, such as promoting bone resorption and decreasing bone formation, but the direct inhibition of calcium absorption is a key mechanism that contributes significantly to the overall risk of osteoporosis. The complex interplay of these factors illustrates how glucocorticoids can severely impact bone health over extended periods of use.

Understanding this mechanism is crucial for managing patients on glucocorticoid therapy and implementing preventative measures for bone health, such as adequate calcium and vitamin D supplementation, alongside monitoring bone density.