What effect does sirolimus have on renal function compared to calcineurin inhibitors?

Sirolimus is known for its renal protective qualities, particularly when compared to calcineurin inhibitors such as cyclosporine and tacrolimus. Calcineurin inhibitors are associated with nephrotoxicity and can lead to dose-dependent kidney damage, including effects on renal blood flow and glomerular filtration rate.

In contrast, sirolimus, which is an mTOR inhibitor, does not exhibit the same nephrotoxic effects. It has been shown to have a more favorable profile when it comes to preserving renal function, especially in transplant patients. Sirolimus protects against the detrimental effects on the kidneys that are commonly seen with calcineurin inhibitors, making it a preferred choice in certain clinical settings where kidney preservation is a priority. Therefore, its renal protective effect is a significant aspect of its therapeutic use, particularly in long-term management.