What is a key effect expected after the release of cortisol from the adrenocorticosteroid synthetic pathway?

The release of cortisol from the adrenocorticosteroid synthetic pathway leads to several physiological effects, with increased gluconeogenesis being one of the most significant. Cortisol, a glucocorticoid hormone, plays a pivotal role in glucose metabolism. When cortisol levels rise, such as during stress or fasting, the liver is stimulated to produce more glucose through gluconeogenesis, which involves the conversion of non-carbohydrate substrates like amino acids and glycerol into glucose. This process results in increased blood glucose levels and provides the body with an essential energy source during times of need.

In addition to gluconeogenesis, cortisol also has other metabolic effects, such as promoting protein catabolism and lipid mobilization for energy, but the enhancement of gluconeogenesis specifically supports the body's need to maintain adequate glucose supplies for critical functions, particularly in the brain.

Cortisol's actions are vital during stress response, contributing to the maintenance of homeostasis and ensuring that energy demands are met.