What is a notable feature of local administration of alprostadil?

Local administration of alprostadil is notable for allowing for low systemic absorption. This is significant because it minimizes the risk of systemic side effects that can occur when medications are absorbed throughout the body. Alprostadil is used primarily for treating erectile dysfunction and can be administered locally to the penis via injection or a urethral suppository. The localized delivery ensures that the medication exerts its effects directly at the site of action while reducing the likelihood of affecting other systems in the body, which may lead to unwanted side effects.

This feature of local administration is particularly advantageous since it allows for higher concentrations of the drug at the target site, leading to improved efficacy while maintaining a greater level of safety regarding systemic exposure. This selective delivery is essential in therapeutic contexts where targeting a specific area is crucial to the desired outcome.