What is the desirable serum digoxin level for treating atrial fibrillation?

The desirable serum digoxin level for treating atrial fibrillation typically falls within the range of 1 to 2 ng/mL. This range is considered therapeutic and is aimed at achieving optimal drug efficacy while minimizing the risk of toxicity.

Digoxin is utilized in the management of atrial fibrillation to help control heart rate and improve cardiac output. Levels below 1 ng/mL might not provide sufficient pharmacologic effect, risking the reversion of symptoms, while values above 2 ng/mL increase the likelihood of adverse effects, including toxicity, which is particularly concerning in patients who may have renal impairment or are on other medications that interact with digoxin.

Furthermore, monitoring digoxin levels is essential since individual patient responses can vary significantly based on factors such as renal function and concomitant medications. Therefore, maintaining the serum digoxin level within the range of 1 to 2 ng/mL ensures that the treatment remains both effective and safe.