What is the effect of naproxen regarding cardiovascular disease?

Naproxen is considered to have a favorable safety profile regarding cardiovascular disease compared to other nonsteroidal anti-inflammatory drugs (NSAIDs). Multiple studies have shown that while some NSAIDs, particularly selective COX-2 inhibitors like diclofenac and rofecoxib, are associated with an increased risk of cardiovascular events such as heart attacks and strokes, naproxen does not carry the same level of concern.

In fact, clinical guidelines often suggest that naproxen may be a preferred choice for patients who require NSAID therapy and have cardiovascular risk factors, due to its relatively lower cardiovascular risk profile. This characteristic sets naproxen apart and supports its designation as the safest NSAID in terms of cardiovascular implications among the non-selective NSAIDs.

Overall, the unique aspect of naproxen's risk profile informs decisions in clinical practice, particularly for patients with existing cardiovascular disease or risk factors, reinforcing its position as a safer option within its class.