What is the key therapeutic effect of azelaic acid in treating acne?

Azelaic acid is primarily recognized for its ability to lighten hyperpigmented areas, making it an effective treatment for acne-related discoloration, such as post-inflammatory hyperpigmentation. This characteristic stems from its action on melanin production, where azelaic acid can inhibit the enzyme tyrosinase, which is crucial for melanin biosynthesis.

By addressing hyperpigmentation, azelaic acid not only improves the overall appearance of the skin following acne lesions, but it also helps mitigate some of the emotional and psychological impacts associated with visible skin concerns. Its ability to even out skin tone contributes significantly to its therapeutic value in acne treatment, particularly for individuals dealing with the aftereffects of acne.

Although azelaic acid has other beneficial properties, such as its antibacterial activity and effects on reducing oil production and increasing skin turnover, the primary focus here is on its effectiveness in lightening skin discolorations. Thus, its role in treating hyperpigmented areas is a crucial aspect of its therapeutic effect in acne management.