What is the most appropriate drug to treat the cardiovascular symptoms of amphetamine overdose?

In the context of treating cardiovascular symptoms resulting from an amphetamine overdose, the most appropriate choice is a drug that effectively manages elevated blood pressure and heart rate due to sympathetic overstimulation. Labetalol is a beta-blocker that also has alpha-blocking properties, making it adept at reducing both heart rate and blood pressure.

Amphetamines lead to increased norepinephrine release and heightened adrenergic tone, resulting in symptoms such as tachycardia and hypertension. Labetalol's dual action allows it to address these symptoms by blocking beta-adrenergic receptors, which reduces heart rate, while its alpha-blocking activity helps in vasodilation, consequently lowering blood pressure.

The other mentioned options offer more selective effects or different pharmacologic profiles that may not adequately address the broad cardiovascular effects seen in amphetamine overdose. Metoprolol is a selective beta-1 blocker, which primarily reduces heart rate but does not address vasodilation. Prazosin is an alpha-1 blocker that primarily causes vasodilation and might not adequately control heart rate in this specific scenario. Nebivolol, while a beta-blocker with some vasodilatory properties, may not provide the rapid and effective control needed in the acute management of