What therapeutic intervention can lower salicylate absorption following an overdose?

Activated charcoal is a common intervention used to reduce the absorption of many substances, including salicylates, in cases of overdose. It acts by binding to the salicylate in the gastrointestinal tract, preventing its absorption into the bloodstream. Whole bowel irrigation can also be used in cases of overdose; it helps to flush out the gastrointestinal tract. This method is particularly effective when the ingested substance is not well absorbed by charcoal or when large amounts of a substance have been consumed.

Both activated charcoal and whole bowel irrigation can be effective strategies for minimizing salicylate absorption after an overdose. Their combined use allows for a more comprehensive approach to managing the overdose, ensuring that as much of the ingested salicylate as possible is removed from the system and decreasing the risk of further systemic effects. This combination, therefore, is the most effective therapeutic intervention available in this scenario.