Which agent is most appropriate for initiating treatment of influenza in a 75-year-old man with COPD?

The most appropriate agent for initiating treatment of influenza in a 75-year-old man with COPD is Oseltamivir. This medication belongs to a class of antiviral drugs known as neuraminidase inhibitors, which are effective in treating influenza types A and B. Oseltamivir acts by inhibiting the neuraminidase enzyme, preventing the release of viral particles and thus limiting the spread of the virus within the respiratory tract.

In elderly patients, especially those with underlying chronic conditions like COPD, timely antiviral treatment is crucial to reduce the risk of severe complications from influenza. Oseltamivir is particularly favored in this population due to its oral administration, ease of use, and effectiveness. It can be started soon after the onset of symptoms, ideally within 48 hours, to provide the maximum benefit.

Zanamivir, another neuraminidase inhibitor, is also effective against influenza but is administered via inhalation, which may pose challenges for a patient with compromised lung function due to COPD. This route of administration could potentially exacerbate respiratory issues.

Rimantadine and Amantadine are antiviral agents that specifically target influenza A viruses. However, they are not recommended for use due to concerns about resistance, especially in the elderly and in patients with chronic