Which anesthetic agent is most appropriate for a patient with a family history of malignant hyperthermia?

In patients with a family history of malignant hyperthermia, it is crucial to choose anesthetic agents that do not trigger this serious and potentially life-threatening condition. Malignant hyperthermia is a hypermetabolic reaction to certain anesthetics, particularly volatile anesthetics like isoflurane and sevoflurane, as well as the depolarizing muscle relaxant succinylcholine.

Propofol stands out as the most suitable anesthetic choice because it is not associated with the triggering of malignant hyperthermia. This intravenous anesthetic is widely used for induction and maintenance of anesthesia and has a favorable safety profile for patients with this susceptibility. By utilizing propofol, the anesthesiologist minimizes the risk of inducing malignant hyperthermia, making it the safest option given the patient’s history.

In contrast, isoflurane and sevoflurane are volatile anesthetics known to cause malignant hyperthermia in susceptible individuals, and succinylcholine also poses a risk as it can trigger this condition. Therefore, propofol is the appropriate agent in this scenario, prioritizing patient safety and the avoidance of malignant hyperthermia disorders.