Which antibiotic is associated with acute Achilles tendon rupture?

Levofloxacin, a fluoroquinolone antibiotic, is associated with an increased risk of acute Achilles tendon rupture. This adverse effect can occur due to the drug’s interference with tendon repair and its impact on collagen synthesis. Fluoroquinolones, including levofloxacin, are known to cause tendon damage, particularly in older adults or those with predisposing factors such as concurrent use of corticosteroids or a history of tendon disorders.

In contrast, the other antibiotics listed do not carry a similar risk. Amoxicillin/clavulanate, cefdinir, and minocycline do not have documented associations with acute tendon ruptures. Understanding the specific side effects and risks associated with different antibiotics is crucial for safe prescribing, particularly for patients with conditions that may predispose them to tendon injuries.