Which antihypertensive medication is known to cause the rare side effect of angioedema?

The antihypertensive medication known to cause the rare side effect of angioedema is Fosinopril. This medication is an ACE (angiotensin-converting enzyme) inhibitor, which works by preventing the conversion of angiotensin I to angiotensin II, leading to vasodilation and decreased blood pressure. ACE inhibitors, including Fosinopril, can result in the accumulation of bradykinin, a peptide that can cause increased vascular permeability and tissue swelling, which is the underlying mechanism behind angioedema.

While other medications such as Amlodipine (a calcium channel blocker), Prazosin (an alpha-1 antagonist), and Propranolol (a beta-blocker) are effective for hypertension, they do not have the same risk of inducing angioedema as seen with ACE inhibitors. This side effect is particularly significant in certain populations and can manifest as facial swelling, difficulty breathing, and gastrointestinal distress, making it an important consideration when prescribing Fosinopril or any other ACE inhibitor.