Which antipsychotic is known for its sedative potential and is sometimes used as a sedative-hypnotic?

Quetiapine is recognized for its sedative properties and is often utilized as a sedative-hypnotic in clinical practice. This atypical antipsychotic has a unique pharmacological profile that sets it apart from other antipsychotics. It has a moderate affinity for various receptors, including histamine H1 receptors, which contributes to its sedative effects. When used in lower doses, quetiapine can be effective for managing insomnia or anxiety, making it appealing for off-label use as a sleep aid.

In contrast, other antipsychotics listed are primarily utilized for their antipsychotic effects and do not possess the same level of sedative potential. Fluphenazine and haloperidol, for example, are first-generation antipsychotics with a focus on controlling psychosis rather than inducing sedation. Thiothixene, also a first-generation antipsychotic, similarly lacks significant sedative properties compared to quetiapine. Thus, the distinctive sedative-hypnotic nature of quetiapine makes it the correct answer in this context.