Which class of medication is generally prescribed for preventing osteoporosis-related fractures in high-risk patients?

Bisphosphonates are a class of medications that are specifically designed to prevent bone loss and fractures associated with osteoporosis, particularly in high-risk patients. These medications work by inhibiting osteoclast-mediated bone resorption, which helps to increase bone density and reduce the risk of fractures. Common bisphosphonates include alendronate, risedronate, and zoledronic acid, which are frequently prescribed for postmenopausal women and individuals with other risk factors for osteoporosis.

In contrast, the other classes mentioned do not have a primary role in preventing osteoporosis-related fractures. Antidepressants primarily target mood disorders and are not designed to influence bone density. Benzodiazepines are used for anxiety and sleep disorders and do not impact bone health. Opioids are pain-relieving medications and are not intended for the prevention or treatment of osteoporosis. Therefore, bisphosphonates are clearly the appropriate choice for this purpose.