Which drug is known for its potential to cause infusion reactions?

Amphotericin B is well known for its potential to cause infusion reactions, which can manifest as fever, chills, rigors, and hypotension. These reactions are attributed to the drug's mechanism of action and its effect on the immune system. When Amphotericin B is infused, the body may react to the alteration of cytokines and other inflammatory mediators released as a response to the drug's presence, leading to these adverse effects. This is particularly notable with the traditional formulation of Amphotericin B, as it can trigger significant reactions during administration.

In contrast, Micafungin and Anidulafungin, which are echinocandin class antifungals, are less commonly associated with infusion-related reactions. While they may have some side effects, the acute reactions observed with Amphotericin B are not typical for these two drugs. Fluconazole, a triazole antifungal, is generally well-tolerated and does not typically cause infusion reactions, making it a safer option in terms of immediate infusion-related side effects. Therefore, Amphotericin B stands out as the drug most frequently linked to such reactions during infusion.