Which medication is most appropriate for managing seasonal allergies in a person whose job requires alertness?

Fexofenadine is the most appropriate choice for managing seasonal allergies in a person whose job requires alertness due to its classification as a second-generation antihistamine. Unlike first-generation antihistamines such as diphenhydramine, doxylamine, and hydroxyzine, fexofenadine has a lower propensity to cross the blood-brain barrier, which means it is less likely to cause sedation and drowsiness. This characteristic is crucial for individuals who need to maintain alertness in their jobs.

First-generation antihistamines commonly lead to central nervous system effects such as sedation, which can impair cognitive functions and physical performance. Therefore, while they may be effective for allergy relief, they are generally not suitable for people who must remain alert and attentive. In contrast, fexofenadine provides effective relief from allergy symptoms, such as sneezing and itching, without the side effects associated with sedation. This makes it an ideal option for individuals whose work demands high levels of concentration and alertness.