Which of the following can be a consideration with the use of Ezetimibe?

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Ezetimibe is a medication that primarily works by inhibiting the absorption of cholesterol in the small intestine. This mechanism effectively reduces the amount of cholesterol that enters the bloodstream, leading to decreased levels of LDL cholesterol and total cholesterol. This action makes Ezetimibe an important therapeutic option for patients who require additional lipid-lowering effects, particularly those who may not reach their cholesterol targets with statins alone.

It's also worth noting that Ezetimibe can be used in combination with statins to enhance cholesterol-lowering efficacy, thus improving overall lipid profiles in patients with hyperlipidemia. This synergistic effect helps address the limitations some patients face with statin therapy alone.

Considering the other options, the side effects and specific uses of Ezetimibe clarify why those choices do not fit. For instance, while Ezetimibe has been shown to have minimal effects on triglyceride levels, it does not inherently increase them. Additionally, it is not a first-line treatment for all patients; instead, it is typically reserved as adjunctive therapy after lifestyle changes and primary treatments like statins. Furthermore, Ezetimibe is not rendered ineffective when used in conjunction with statins; rather, they can work together to provide a more comprehensive approach

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