Which of the following is a common side effect of topical corticosteroids when used excessively?

When topical corticosteroids are used excessively, one of the most notable side effects is skin atrophy. Topical corticosteroids are potent anti-inflammatory agents that can lead to thinning of the skin over time. This occurs because they interfere with the normal functions of skin cells and the skin’s ability to regenerate. The long-term application can result in a decrease in collagen content and structural integrity of the skin, which is manifest as atrophy, leading to a wrinkled appearance and increased fragility of the skin.

This side effect is particularly important to monitor, especially in areas where the skin is thinner, such as the face or skin folds, which may be more susceptible to atrophy. Awareness of this potential side effect is crucial for practitioners and patients alike, highlighting the importance of using these medications judiciously and under proper medical supervision to minimize adverse effects while still achieving therapeutic benefits.