Which patient with iron deficiency anemia would benefit most from parenteral iron replacement?

The patient with end-stage renal disease on hemodialysis would benefit most from parenteral iron replacement due to several key factors related to iron deficiency anemia and the management of chronic kidney disease. In patients with end-stage renal disease, especially those undergoing hemodialysis, iron deficiency is common due to several reasons. These include blood loss during dialysis, reduced production of erythropoietin leading to decreased red blood cell production, and poor dietary intake.

Parenteral iron is typically preferred in this patient population because oral iron supplements may not be adequately absorbed, and the need for rapid replenishment of iron stores is often critical to help manage anemia and support erythropoiesis. Hemodialysis patients are also frequently monitored for anemia, and ensuring an effective response to treatment is vital, making intravenous iron formulations a more suitable option.

In contrast, while heavy menstrual bleeding can lead to iron deficiency in the young woman, her condition may initially be managed with oral iron. The pregnant woman in her first trimester may also respond adequately to oral iron supplementation, and careful monitoring is essential during pregnancy. The man with a diabetic foot infection, although he may have other considerations related to his overall health and healing process, does not have a primary issue