Which sedative-hypnotic utilizes melatonin receptor agonist as its mechanism of action?

Tasimelteon is known for its mechanism of action as a melatonin receptor agonist. This medication specifically targets the melatonin receptors in the body to regulate the sleep-wake cycle, making it effective for treating sleep disorders, particularly non-24-hour sleep-wake disorder in blind individuals. By mimicking the action of melatonin, tasimelteon helps to promote sleep in a natural manner.

In contrast, other sedative-hypnotics like zolpidem, eszopiclone, and estazolam primarily work by enhancing gamma-aminobutyric acid (GABA) activity at the GABA-A receptors. This action leads to increased inhibitory neurotransmission, resulting in sedative and hypnotic effects. However, their mechanism differs from that of tasimelteon, highlighting why this specific agent is unique in its approach by directly acting on melatonin receptors rather than GABA receptors.