Which side effect is least likely associated with the use of medroxyprogesterone acetate?

Medroxyprogesterone acetate, a synthetic form of progesterone, is commonly used in various therapeutic contexts, including contraception and hormone replacement therapy. Among the listed side effects, hair loss is the least likely to be associated with its use.

Bone density loss, weight gain, and mood swings are well-documented potential side effects of medroxyprogesterone acetate. The drug can lead to a reduction in bone mineral density, particularly with long-term use, which raises concerns, especially in younger women. Weight gain is frequently reported by patients due to its impact on metabolism and appetite. Mood swings can occur as a result of hormonal changes caused by the medication, similar to how other hormonal therapies may affect emotional regulation.

In contrast, while hormonal medications can influence hair growth and shedding due to fluctuations in hormone levels, significant hair loss is not a commonly documented side effect of medroxyprogesterone acetate. Therefore, among the listed options, hair loss stands out as the least likely side effect associated with this medication.