Which vitamin should be included in the regimen of a patient receiving isoniazid to reduce the risk of peripheral neuropathy?

For a patient receiving isoniazid, including pyridoxine (vitamin B6) in their regimen is important to mitigate the risk of peripheral neuropathy. Isoniazid, which is commonly used to treat tuberculosis, can lead to vitamin B6 depletion by interfering with its metabolism. This can ultimately result in neurological side effects, including peripheral neuropathy.

Pyridoxine plays a crucial role in the synthesis of neurotransmitters and the maintenance of proper nerve function. Supplementing with pyridoxine counteracts the adverse effects of isoniazid on this vitamin, helping to prevent the neurological complications that may arise from the treatment.

Other vitamins listed, such as niacin, thiamine, and ascorbic acid, do not specifically address the neurological side effects associated with isoniazid and do not have the same protective effect against peripheral neuropathy. Therefore, pyridoxine is the most appropriate choice for this particular concern.