Which weight loss medication is considered for an obese patient with depression?

The medication that is most suitable for an obese patient with depression is bupropion + naltrexone. This combination works effectively for weight loss while also offering benefits for individuals dealing with depression, as bupropion is an antidepressant that can help improve mood and alleviate depressive symptoms.

Bupropion, specifically, is known for its stimulating effects compared to other antidepressants, which can be beneficial for individuals struggling with obesity and depression, as it may help with both weight loss and mood stabilization. Naltrexone works synergistically with bupropion to reduce food cravings and promote weight loss.

In contrast, liraglutide, orlistat, and lorcaserin don’t address the psychological aspect of weight management as effectively. Liraglutide primarily focuses on appetite regulation and blood glucose control, orlistat prevents fat absorption in the gut but does not influence mood or psychological conditions, and lorcaserin acts primarily as a selective serotonin receptor agonist to reduce appetite without specifically addressing depression.

Thus, the combination of bupropion and naltrexone is particularly advantageous for a patient who is both obese and suffering from depression, making it the most appropriate choice.